The risky investment game of Gneezy and Potters :631–645, 1997) has been proposed as a simple tool to measure risk aversion in applied settings, especially attractive in settings where participants may have limited education. However, this game can produce a significant endowment effect, so that analysis of the behavior in this game should not be done in the Expected Utility Theory framework. The paper illustrates this point, by showing that risk tolerance can be much higher when the initial endowment concerns (...) a risky lottery. (shrink)

The growth of esports as a recognized, organized, competitive activity in North America and Europe has evolved steadily from one of the most prominent sport industries in several Asian countries. Esports, which is still pursuing a widely accepted governance structure, has struggled to control the factors that typically act as a breeding ground for sport corruption. Within the esports industry, there is alleged widespread use of both prescription and off-label use of stimulants, such as modafinil, methylphenidate, and dextroamphetamine. Anti-doping policy (...) implementation in this environment may result in either the abuse of the Therapeutic Use Exemptions system or excluding too many competitors who have a legitimate need for these medications. In this paper, we contextualize esports and substance use within this emerging industry. Subsequently, we outline the specific challenges faced by esports organizations in crafting policies to address PEDs—one of the industry’s most pressing issues. Furt... (shrink)

Human neural and behavioral activities have been reported to exhibit fractal dynamics known as 1/f noise, which is more aptly named 1/f scaling. Some argue that 1/f scaling is a general and pervasive property of the dynamical substrate from which cognitive functions are formed. Others argue that it is an idiosyncratic property of domain‐specific processes. An experiment was conducted to investigate whether 1/f scaling pervades the intrinsic fluctuations of a spoken word. Ten participants each repeated the word bucket over 1,000 (...) times, and fluctuations in acoustic measurements across repetitions generally followed the 1/f scaling relation, including numerous parallel yet distinct series of 1/f fluctuations. On the basis of work showing that 1/f scaling is a universal earmark of metastability, it is proposed that the observed pervasiveness of 1/f fluctuations in speech reflects the fact that cognitive functions are formed as metastable patterns of activity in brain, body, and environment. (shrink)

After fifteen years as an award-winning educator, Ryan Stein knows this: when you make the school experience about fostering genuine human connection, students don't just succeed-they thrive. In this part-guidebook, part-memoir, Ryan shares the best ideas and stories from his groundbreaking educational philosophy with anyone seeking to make a positive difference in a student's life. "Lifeline 65" is as joyful as it is useful, packed full of wit, humor, and heart. Try even one strategy and you'll find your students (...) more engaged, confident, and eager to excel, from elementary school to college and beyond. All you have to do is begin. (shrink)

All of our information about the world is derived from the function of our senses, and thus they are the principal source of all our knowledge. This was recognized explicitly by early Greek philosophers, remained an important point of discussion for nineteenth‐century philosophers, and continues to be a key issue for present‐day philosophers, psychologists, and neuroscientists. It is a key issue in cognitive science because, by initiating the processes that store and evaluate information, sensory information transmission can be considered a (...) cognitive initiator. In a very real sense, who we are and how we see the world are the result of the experiences that are mediated by our sensory systems. These are some of the reasons why the study of sensory systems has occupied such a prominent place in modern cognitive neuroscience. (shrink)

Perhaps the central focus of American bioethics has been to push against medical paternalism on the grounds that it impedes the autonomy of patients—that is, their ability to make choices of their...

Religious and Ethical Perspectives on Global Migration examines the complicated social ethics of migration in today's world. Editors Elizabeth W. Collier and Charles R. Strain bring the perspectives of an international group of scholars toward a theory of justice and ethical understanding for the nearly two hundred million migrants who have left their homes seeking asylum from political persecution, greater freedom and safety, economic opportunity, or reunion with family members.

Dispositional forgiveness is positively associated with many facets of wellbeing and has protective implications against depression and anxiety in adolescents. However, little work has been done to examine neurobiological aspects of forgiveness as they relate to clinical symptoms. In order to better understand the neural mechanisms supporting the protective role of forgiveness in adolescents, the current study examined the middle frontal gyrus, which comprises the majority of the dorsolateral prefrontal cortex and is associated with cognitive regulation, and its relationship to (...) forgiveness and clinical symptoms in a sample of healthy adolescents. In this cross-sectional study, larger MFG volume was significantly associated with higher self-reported dispositional forgiveness scores and lower levels of depressive and anxiety symptoms. Forgiveness mediated the relationship between MFG volume and both depressive and anxiety symptom levels. The mediating role of forgiveness in the relationship between MFG volume and clinical symptoms suggests that one way that cognitive regulation strategies supported by this brain region may improve adolescent mental health is via increasing a capacity for forgiveness. The present study highlights the relevance of forgiveness to neurobiology and their relevance to emotional health in adolescents. Future longitudinal studies should focus on the predictive quality of the relationship between forgiveness, brain volume and clinical symptoms and the effects of forgiveness interventions on these relationships. (shrink)

'Gemeinwohl" (Common Good) galt über lange Zeit als eine Schlüsselkategorie christlicher Sozialethik. Diese Selbstverständlichkeit ist einem selbstkritischen Sozialkatholizismus sowohl in der Theorie als auch im politisch-ethischen Praxisbezug abhandengekommen. Ist der Appell an die Gemeinwohlverpflichtung mehr als ein diffuses und hilfloses Postulat? Lässt sich, zumal unter den Bedingungen globaler Verflechtungen und Abhängigkeiten, mit dieser Kategorie sozial-ethische Relevanz erzeugen? Wie verhält sich die Vorstellung einer sozialen Ganzheit zu der Pluralität von Vorstellungen des guten Lebens und zu der Vielheit von Interessen? Was legitimiert (...) und welche Akteure tragen eine soziale Ordnung? Wie verhält sich eine Theorie des Gemeinwohls zu Theorien öffentlicher Güter (Commons),,angesichts internationaler Herausforderungen wie Migration, Klimapolitik, Welthandel oder Finanzmarktregulierung'' Die Beiträge des Bandes gehen zurück auf die Jahrestagung 2019 der,,Arbeitsgemeinschaft Christliche Sozialethik'', die der Frage nach dem,,globalen Gemeinwohl" gewidmet war."-- Back cover. (shrink)

This paper explores early Australasian philosophy in some detail. Two approaches have dominated Western philosophy in Australia: idealism and materialism. Idealism was prevalent between the 1880s and the 1930s, but dissipated thereafter. Idealism in Australia often reflected Kantian themes, but it also reflected the revival of interest in Hegel through the work of ‘absolute idealists’ such as T. H. Green, F. H. Bradley, and Henry Jones. A number of the early New Zealand philosophers were also educated in the idealist tradition (...) and were influential in their communities, but produced relatively little. In Australia, materialism gained prominence through the work of John Anderson, who arrived in Australia in 1927, and continues to be influential. John Anderson had been a student of Henry Jones, who might therefore be said to have influenced both main strands of Australian philosophical thought. (shrink)

The honour of being the first to teach philosophy in Australia belongs to the Congregationalist minister Barzillai Quaife (1798–1873), in the 1850s, but teaching philosophy did not formally begin until the 1880s, with the establishment of universities (Grave 1984). -/- Two approaches have dominated Western philosophy in Australia: Idealism and materialism. Idealism was prevalent between the 1880s and the 1930s, but dissipated thereafter. It was particularly associated with the work of the first professional philosophers in Australia, such as Henry Laurie (...) (1837–1922), Francis Anderson (1858–1941), William Mitchell (1861–1962) (who rejected the label) and a second generation including W. R. Boyce Gibson (1869–1935). Idealism in Australia often reflected Kantian themes, together with the British, particularly Scottish, revival of interest in Hegel through the work of the ‘Absolute Idealists’ T. H. Green (1836–1882), F. H. Bradley (1846–1924) and Henry Jones (1852–1922), the latter of whom conducted a popular lecture tour of Australia (Boucher 1990). -/- A number of the early New Zealand philosophers, including Duncan MacGregor (1843–1906), William Salmond (1835–1917), and Francis W. Dunlop (1874–1932) were educated in the Idealist tradition and were influential in their communities, but produced relatively little. William Anderson (1889–1955), at Auckland, brother of John at Sydney, was the only New Zealand philosopher that seemed to retain Idealist views. -/- In Australia, materialism gained prominence through the work of John Anderson, who arrived in Australia in 1927, and continues to be influential. John Anderson had been a student of Henry Jones, who can be said to have influenced both strands of Australian philosophical thought. (shrink)

Diseases caused by Salmonella species are characterized by bacterial invasion of host cells. Salmonella invasion requires a genetic locus (inv) with homology to bacterial systems involved in specific protein export and organelle assembly. Until recently, the actual Salmonella invasion factors exported or assembled by the inv system remained unidentified. It now appears that Salmonella produces novel appendages upon contact with host cells. These appendages are transient, appearing and disappearing rapidly from the bacterial surface. Appendages are altered in strains unable to (...) invade due to mutations within the inv/spa locus. Therefore, a role for the invasion locus has been identified, providing another example of bacterial pathogens responding to signals provided by the host cell surface. (shrink)

Many people have an aptitude for religious experience and spirituality but don't know how to develop this or take it further. Modern societies offer little assistance, and traditional religions are overly preoccupied with their own organizational survival. Minding the Self: Jungian meditations on contemporary spirituality offers suggestions for individual spiritual development in our modern and post-modern times. Here, Murray Stein argues that C.G. Jung and depth psychology provide guidance and the foundation for a new kind of modern spirituality.Murray (...) class='Hi'>Stein explores the problem of spirituality within the cultural context of modernity and offers a way forward without relapsing into traditional or mythological modes of consciousness. Chapters work towards finding the proper vessel for contemporary spirituality and dealing with the ethical issues that crop up along the way. Stein shows how it is an individual path but not an isolationist one, often using many resources borrowed from a variety of religious traditions: it is a way of symbol, dream and experiences of the numinous with hints of transcendence as these come into personal awareness. Minding the Self: Jungian meditations on contemporary spirituality uses research from a wide variety of fields, such as dream-work and the neuroscience of the sleeping brain, clinical experience in Jungian psychoanalysis, anthropology, ethics, Zen Buddhism, Jung's writings and the recently published Red Book. It will be of interest to psychoanalysts, Jungian scholars, undergraduates, graduate and post-graduate students and anyone with an interest in modern spirituality. (shrink)

In spite of accelerated economical growth disadvantaged groups might be »non-winners« of a European Single Market now determinating the structures of any future »European House«. The responsibility of diaconia is to prevent a split between those citizens who are able to of T er mobility and flexibility and rely on effective multinational pressure-groups and those who do not. With help from concerned organs of the E. C. diaconia might benefit from an enhanced exchange of experiences, define the social responsibility of (...) the churches in Europe and participate in the shaping of a common future. (shrink)

Nichts anderes meint die romantische Ironie, als das Spiel des Lebens, das ein Widerspiel der Welt ist, auch wirklich als Spiel zu nehmen und darzustellen, aber: »Darstellung ist Sache der Kunst« und »Darstellen kann nur der Mensch.« So avanciert in der ästhetisch gedeuteten Tathandlung das allein zur Darstellung befähigte Bewußtsein zum »complementum existentiae« der äußeren Welt, indem es Darstellungen einer Welt hervorbringt, die nur in den Darstellungen ihre vielfältige Wirklichkeit oder wirkliche Vielfalt zum Dasein bringt. Jenseits und vorgängig dieser Darstellungen (...) liegt das Nichts der Möglichkeiten zur unendlichen Fülle, das Chaos, aus dem der Verstand diese eine unendliche Welt von Welten bildet. Aus dem Zusammenspiel von Chaos als der Grundlage aller Natur, also auch der menschlichen, in der es sich in der »schönen Verwirrung der Fantasie« manifestiert, und Verstand, der ebenso auch als natürlicher, im Sinne von Energie, aufzufassen ist, entspringt erst die eine Welt in der Unendlichkeit ihrer verdichteten Darstellungen. Diese Strukturierungsleistung aber obliegt der Poesie, eine Aufgabe, die sie wiederum mit der Natur selbst verbindet. Dieses mit bedenkend wird sich die Poesie nicht nur ihrer eigenen Voraussetzungen bewußt, sondern sie wird diese in ihr Produkt aufnehmen. Sie wird »Transzendentalpoesie« oder »progressive Universalpoesie«, deren eigentliches Wesen darin besteht, nie vollendet werden zu können, deren Unvollendung eben die Unvollendung der Welt darstellt. (shrink)

Nichts anderes meint die romantische Ironie, als das Spiel des Lebens, das ein Widerspiel der Welt ist, auch wirklich als Spiel zu nehmen und darzustellen, aber: »Darstellung ist Sache der Kunst« und »Darstellen kann nur der Mensch.« So avanciert in der ästhetisch gedeuteten Tathandlung das allein zur Darstellung befähigte Bewußtsein zum »complementum existentiae« der äußeren Welt, indem es Darstellungen einer Welt hervorbringt, die nur in den Darstellungen ihre vielfältige Wirklichkeit oder wirkliche Vielfalt zum Dasein bringt. Jenseits und vorgängig dieser Darstellungen (...) liegt das Nichts der Möglichkeiten zur unendlichen Fülle, das Chaos, aus dem der Verstand diese eine unendliche Welt von Welten bildet. Aus dem Zusammenspiel von Chaos als der Grundlage aller Natur, also auch der menschlichen, in der es sich in der »schönen Verwirrung der Fantasie« manifestiert, und Verstand, der ebenso auch als natürlicher, im Sinne von Energie, aufzufassen ist, entspringt erst die eine Welt in der Unendlichkeit ihrer verdichteten Darstellungen. Diese Strukturierungsleistung aber obliegt der Poesie, eine Aufgabe, die sie wiederum mit der Natur selbst verbindet. Dieses mit bedenkend wird sich die Poesie nicht nur ihrer eigenen Voraussetzungen bewußt, sondern sie wird diese in ihr Produkt aufnehmen. Sie wird »Transzendentalpoesie« oder »progressive Universalpoesie«, deren eigentliches Wesen darin besteht, nie vollendet werden zu können, deren Unvollendung eben die Unvollendung der Welt darstellt. (shrink)

The least attentive Hellenist must have noticed that the Greek tongue contains a number of pairs of nouns of identical or nearly related meaning—one in the masculine, the other in the feminine. The subject attracted the notice of Lobeck, Pathoiogia, pp. 7 sq., Technologia, pp. 267 sq.; G. Meyer in Curtius' Studien V., p. 68; Stein in the introduction to his Herodotus, p. lx ; and the resultant list will be found in Kuhner-Blass I., pp. 501, 502. It is (...) not complete , and the question deserves investigation. The only doctrine that can be called such appears to be the remark in schol. BT on Σ 551 , δρεπανας] Iωνκως, οủτο αρ τρεπουσ πάντα είς τφρη, ταρη αστρααλη. (shrink)

The least attentive Hellenist must have noticed that the Greek tongue contains a number of pairs of nouns of identical or nearly related meaning—one in the masculine, the other in the feminine. The subject attracted the notice of Lobeck, Pathoiogia, pp. 7 sq., Technologia, pp. 267 sq.; G. Meyer in Curtius' Studien V., p. 68; Stein in the introduction to his Herodotus, p. lx ; and the resultant list will be found in Kuhner-Blass I., pp. 501, 502. It is (...) not complete, and the question deserves investigation. The only doctrine that can be called such appears to be the remark in schol. BT on Σ 551, δρεπανας] Iωνκως, οủτο αρ τρεπουσ πάντα είς τφρη, ταρη αστρααλη. (shrink)

In Minkowski spacetime, because of the relativity of simultaneity to the inertial frame chosen, there is no unique world-at-an-instant. Thus the classical view that there is a unique set of events existing now in a three dimensional space cannot be sustained. The two solutions most often advanced are that the four-dimensional structure of events and processes is alone real, and that becoming present is not an objective part of reality; and that present existence is not an absolute notion, but is (...) relative to inertial frame; the world-at-an-instant is a three dimensional, but relative, reality. According to a third view, advanced by Robb, Capek and Stein, what is present at a given spacetime point is, strictly speaking, constituted by that point alone. I argue here against the first of these views that the four-dimensional universe cannot be said to exist now, already, or indeed at any time at all; so that talk of its existence or reality as if that precludes the existence or reality of the present is a non sequitur. The second view assumes that in relativistic physics time lapse is measured by the time co-ordinate function; against this I maintain that it is in fact measured by the proper time, as I argue by reference to the Twin Paradox. The third view, although formally correct, is tarnished by its unrealistic assumption of point-events. This makes it susceptible to paradox, and also sets it at variance with our normal intuitions of the present. I argue that a defensible concept of the present is nonetheless obtainable when account is taken of the non-instantaneity of events, including that of conscious awareness, as that region of spacetime comprised between the forward lightcone of the beginning of a small interval of proper time t and the backward lightcone of the end of that interval. This gives a serviceable notion of what is present to a given event of short duration, as well as saving our intuition of the “reality” or robustness of present events. (shrink)

The exact process that leads to the eruption of autoimmune reactions against β cells and the evolution of diabetes is not fully understood. Macrophages and T cells may launch an initial immune reaction against the pancreatic islets of Langerhans, provoking inflammation and destructive insulitis. The information on the molecular mechanisms of the emergence of β cell injury is controversial and points to possibly important roles for the perforin–granzyme, Fas–Fas-ligand (FasL) and tumor-necrosis-factor-mediated apoptotic pathways. FasL has several unique features that make (...) it a potentially ideal immunomodulatory tool. Most important, FasL is selectively toxic to cytotoxic T cells and less harmful to regulatory T cells. This review discusses the intrinsic sensitivity of β cells to FasL-mediated apoptosis, the conditions that underlie this β cell sensitivity, and the feasibility of using FasL to arrest autoimmunity and prevent islet allograft rejection. In both the autoimmune and transplant settings, it is imperative to progress from the administration of nonspecific immunosuppressive therapy to the concept of β-cell-specific immunomodulation. FasL evolves as a prime candidate for antigen-specific immunomodulation. BioEssays 28: 211–222, 2006. © 2006 Wiley periodicals, Inc. (shrink)

The exact process that leads to the eruption of autoimmune reactions against β cells and the evolution of diabetes is not fully understood. Macrophages and T cells may launch an initial immune reaction against the pancreatic islets of Langerhans, provoking inflammation and destructive insulitis. The information on the molecular mechanisms of the emergence of β cell injury is controversial and points to possibly important roles for the perforin–granzyme, Fas–Fas-ligand (FasL) and tumor-necrosis-factor-mediated apoptotic pathways. FasL has several unique features that make (...) it a potentially ideal immunomodulatory tool. Most important, FasL is selectively toxic to cytotoxic T cells and less harmful to regulatory T cells. This review discusses the intrinsic sensitivity of β cells to FasL-mediated apoptosis, the conditions that underlie this β cell sensitivity, and the feasibility of using FasL to arrest autoimmunity and prevent islet allograft rejection. In both the autoimmune and transplant settings, it is imperative to progress from the administration of nonspecific immunosuppressive therapy to the concept of β-cell-specific immunomodulation. FasL evolves as a prime candidate for antigen-specific immunomodulation. BioEssays 28: 211–222, 2006. © 2006 Wiley periodicals, Inc. (shrink)

On one reading, twentieth century Christian personalists such as Max Scheler, Dietrich von Hildebrand, or Edith Stein merely translate into Christian terms a set of modern concerns that arise apart from and are at odds with the historical Christian tradition. According to this reading, modern philosophy makes a fundamental break with previous thinking when it turns inward to examine the interior, personal dimension of existence. A person who favors this inward turn will see the Christian personalists as vainly attempting (...) to salvage traditional Christian categories while trying to keep up with the times. For example, someone who favors twentieth century existentialism or psychoanalysis may sympathize with a Christian personalist account of the interiority and irreplaceable uniqueness of each person but despise the larger religious framework of grace and salvation. Someone who favors traditional metaphysics, by contrast, may see these personalists as falling prey to modern errors when they should have kept the faith. Such a traditionalist may think, for example, that an emphasis on the personal is an infiltration into Christianity from secular political philosophies of individualism and that this has been thinly covered over with traditional Christian language. -/- Both perspectives, however, ignore the historical roots of personalism much further back in the history of philosophy than Descartes and Kant. Central to this history is the idea that each person uniquely realizes an incommunicable dimension of his existence, irreducible to the category of nature or essence. While we are in nature and while we *are* a nature, our nature as nature remains purely general, describing *what* we are in common with every other member of our species. As particular persons exercising our freedom and spiritual existence, however, each of us concretizes that purely general nature in a unique, personal way. For many centuries, Christians have called the dimension that concretizes nature ὑπόστασις: each ὑπόστασις is a distinct realization of a general nature. When this notion is first introduced into Christian discourse during the second half of the fourth century, the uniqueness of persons as opposed to the uniqueness of individual pebbles or horses does not come fully into focus. Nevertheless, a thick conception of ὑπόστασις develops in order to speak precisely about Trinitarian and Christological theology, and this context gives it a distinctly personalist character, especially when it is translated into Latin as *persona*. In order to speak of God as three ὑποστάσεις or *personae* in one essence and to speak of Christ as one ὑπόστασις or *persona* in two natures, the category of ὑπόστασις must be irreducible to the category of nature. Along this irreducible dimension persons are irreplaceable *someones* in relationship with other someones rather than merely *somethings*, specimens of a kind more or less interchangeable with any other such specimen. (shrink)

In the TV series, Joe Miller is the stop‐cap which keeps James Holden occupied so he does not have time to send constant broadcasts out to the world. When we think about Holden helping others, why he's always in the midst of things, it's helpful to think about what distinguishes Holden from other characters in the series and what makes him unique—that he grew up on a farm. Holden is the exact opposite of Dresden, Strickland, Mao, (...) and Marco. And that's what Naomi loves about him. The Expanse is dark science fiction whose references are to a war of all against all (Thomas Hobbes’ Leviathan), to the massacre of American Indians, and to a dark intelligence that maybe intended the ultimate domination of nature. And one of their protagonists is a guy who thinks he's a knight tilting at windmills. (shrink)

Die Frage nach der Individualität der menschlichen Person gehört zu den Schlüsselfragen jeder Anthropologie. Edith Stein kennt nicht nur eine einmalige Konstellation von äußeren Entwicklungsfaktoren der Person, sondern denkt eine wesentliche Individualität, die für jegliche Entwicklung Voraussetzung ist und sich in einem authentischen Leben als „persönliche Note“ manifestiert. In theologischer Perspektive darf jeder Mensch sich rühmen, „unmittelbar ein Gotteskind zu sein und ein eigenes unwiederholbares Gottessiegel in seiner Seele zu tragen“. Diese Aussage in ihrem Hauptwerk Endliches und ewiges Sein (...) führt Edith Stein zu Überlegungen im Bereich der imago Dei-Lehre, der Leib-Christi-Theologie und der christlichen Mystik. Der Autor verfolgt die Frage in philosophischer und theologischer Perspektive erstmals im ganzen Werk Edith Steins und zeigt dabei die Entwicklung ihres Verständnisses der wesentlichen Individualität jeder Person auf. (shrink)

Das Buch versammelt grundlegende Studien zu Edith Stein und ihren Lektüren von Homer, mittelalterlicher Literatur, Lessing, Schleiermacher, Hauptmann und dem Expressionismus. Es geht den Lektüreeinflüssen in Tradition, Spiritualität und Begegnungen nach und untersucht dazu aktuelle Fragen um Glaube, Wissen und eine neue Phänomenologie. Ein literarisch intensiver und aus der rekonstruierten Bibliothek quellenerschlossener Bildungsgang wirkte auf die Frömmigkeitsentwicklung der späteren Karmelitin und befruchtete massgeblich ihre Denkwelt und mystisch eigene Position.